4/19/2023 0 Comments Amarra symphony 2.4.5MCI is a relatively sensitive index among the various measurable parameters. In conclusion, 3D-STE may help detect early changes in left ventricular myocardial function caused by mFOLFOX6 treatment in patients with colorectal cancer. The correlation observed between MCI and cTnT (r = − 0.7228) was found to be stronger than that between GLS and cTnT (r = − 0.6008). The areas under the ROC curves for MCI and GLS were 0.903 and 0.838, respectively. The absolute values of GAS, GLS, MCI, and LVtw decreased after the first cycle of chemotherapy (P < 0.05). Compared with the pre-chemotherapy state, the absolute values of MCI, LVtw, GLS, GAS, GCS, and GRS decreased with increasing cumulative doses of chemotherapeutic drugs. Receiver operating curves (ROC) were prepared for each parameter and analyzed to identify correlations among MCI, LVEF, GLS, and cTnT. The above listed parameters were compared before and after chemotherapy. Myocardial composite index (MCI) was calculated from measured values (MCI = GLS × LVtw). We used 3D-STE to measure the following parameters of left ventricle function: global longitudinal strain (GLS), global area strain (GAS), global circumferential strain (GCS), global radial strain (GRS), and left ventricular twist (LVtw). Data were collected from 30 patients diagnosed with colorectal cancer in our hospital treated with mFOLFOX6. To evaluate the changes in left ventricular myocardial function in patients with colorectal cancer undergoing chemotherapy with mFOLFOX6 (oxaliplatin + 5-fluorouracil + calcium folinate) using three-dimensional speckle-tracking echocardiography (3D-STE). Moreover, the performance of the model in organ level simulations is illustrated through several multi-field initial-boundary value problems in which we show variations in volume-time relations, heterogeneous characteristics of myocardial contraction and application of a drug in a virtual left ventricle model. Through examples on the material level, we demonstrate that the shape of the ICC and myocardial shortening curves can be easily modified and accurately fitted to experimental data obtained from rat and mouse hearts. The developed approach can be incorporated with phenomenological or biophysically based models of cardiac electrophysiology. The ICC is further put into an exponential-type ODE which determines the shortening of the myocyte (active stretch). The proposed model in this manuscript considers first the evolution of the ICC through a logarithmic-type ordinary differential equation (ODE) having the normalized transmembrane potential as the argument. This study is inspired by the fact that existing models for myocardial contractility either contain a number of complex equations and material parameters, which reduce their feasibility, or are very simple and cannot accurately mimic reality, which eventually influences the realm of computer simulations. In this contribution, we suggest a novel phenomenological approach for myocardial contraction that is capable of producing realistic intracellular calcium concentration (ICC) and myocyte shortening graphs, can be easily calibrated to capture different ICC and contraction characteristics and, at the same time, is straightforward to implement and ensures efficient computer simulations. Due to its vital role for the organism, myocardial contractility is one of the most intensively investigated subjects in medical research. The measurement of the propagation of the local and minute contractile response can reveal the effective contraction with the transmural shearing deformation.Ĭontraction in myocardial tissue is the result of a complex process through which chemical energy on the cellular level is converted into the mechanical energy needed to circulate blood throughout the body. These results indicated that the electrical excitation conducted in each myocardial layer and the transmural shearing deformation occurred at the boundary between alternate layers of contraction and relaxation. The contraction propagated along the direction of the myocardial fiber in the myocardial layer. Alternate layers of contraction and relaxation were observed around the time phase representing the onset of the conduction of electrical excitation. In the present study, we used our previously proposed local velocity estimator to measure the two-dimensional distribution of the strain rate using high-density beam scanning to obtain propagation of the local and minute contractile response in the heart walls of healthy humans. The in vivo measurement of the contractile response caused by electrical excitation has been studied to detect myocardial ischemia in its early stages.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |